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Differential cortical activity for precision and whole-hand visually guided grasping in humans.

Begliomini, C; Wall, MB; Smith, AT; Castiello, U; (2007) Differential cortical activity for precision and whole-hand visually guided grasping in humans. The European journal of neuroscience , 25 (4) 1245–52-1245–52. 10.1111/j.1460-9568.2007.05365.x.

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Abstract

Effective grasping involves the remarkable ability to implement multiple grasp configurations such as precision grip (PG; opposition between the index finger and thumb) and whole-hand grasp (WHG), depending on the properties of the object grasped (e.g. size, shape and weight). In the monkey brain, different groups of cells in the anterior-lateral bank of the intraparietal sulcus (area AIP) are differentially active for various hand configurations during grasping of differently shaped objects. Visually guided grasping studies in humans suggest the anterior intraparietal sulcus (aIPS) as the homologue of macaque area AIP, but leave unresolved the question of whether activity in human aIPS reflects the relationship between object size and grasp configuration, as in macaques. To address this issue, a human fMRI study was conducted in which objects were grasped with the right hand while object size was varied. The results indicated that the left aIPS was active when the subjects naturally adopted a PG to grasp the small object but showed a much weaker response when subjects naturally adopted a WHG to grasp the large object. The primary motor cortex and somatosensory cortices were active for both PG and WHG. Our results suggest that, in humans, the aIPS is centrally involved in determining the type of grasp.

Type: Article
Title: Differential cortical activity for precision and whole-hand visually guided grasping in humans.
DOI: 10.1111/j.1460-9568.2007.05365.x
Publisher version: http://www.ncbi.nlm.nih.gov/pubmed/17331220
Additional information: file: :C$$:/Documents and Settings/mbw97807/Local Settings/Application Data/Mendeley Ltd./Mendeley Desktop/Downloaded/Begliomini et al. - 2007 - Differential cortical activity for precision and whole-hand visually guided grasping in humans..pdf:pdf keywords: Adult,Attention,Attention: physiology,Brain Mapping,Cerebral Cortex,Cerebral Cortex: blood supply,Cerebral Cortex: physiology,Female,Hand Strength,Hand Strength: physiology,Humans,Image Processing, Computer-Assisted,Magnetic Resonance Imaging,Magnetic Resonance Imaging: methods,Male,Motor Cortex,Motor Cortex: blood supply,Motor Cortex: physiology,Motor Skills,Motor Skills: physiology,Oxygen,Oxygen: metabolism,Photic Stimulation,Somatosensory Cortex,Somatosensory Cortex: blood supply,Somatosensory Cortex: physiology pmid: 17331220 shorttitle: Eur J Neurosci
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: http://discovery.ucl.ac.uk/id/eprint/21252
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