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Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer's cramp

Baumer, T; Demiralay, C; Hidding, U; Bikmullina, R; Helmich, RC; Wunderlich, S; Rothwell, J; ... Munchau, A; + view all (2007) Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer's cramp. MOVEMENT DISORD , 22 (1) 81 - 90. 10.1002/mds.21219.

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Abstract

Previous studies demonstrated functional abnormalities in the somatosensory system, including a distorted functional organization of the somatosensory cortex (S I) in patients with writer's cramp. We tested the hypothesis that these functional alterations render S I of these patients more susceptible to the "inhibitory" effects of subthreshold 1 Hz repetitive trans-cranial magnetic stimulation (rTMS) given to SI. Seven patients with writer's cramp and eight healthy subjects were studied. Patients also received rTMS to the motor cortex hand area (M1). As an outcome measure, short-latency afferent inhibition (SAI) was tested. SAI was studied in the relaxed first dorsal interosseous muscle using conditioning electrical stimulation of the index finger and TMS pulses over the contralateral M1. Baseline SAI did not differ between groups. S1 but not M1 rTMS reduced SAI in patients. rTMS had no effects on SAI in healthy subjects. Because SAI is mediated predominantly at a cortical level in the sensorimotor cortex, we conclude that there is an abnormal responsiveness of this area to 1 Hz rTMS in writer's cramp, which may represent a trait toward maladaptive plasticity in the sensorimotor system in these patients. (C) 2006 Movement Disorder Society.

Type: Article
Title: Abnormal plasticity of the sensorimotor cortex to slow repetitive transcranial magnetic stimulation in patients with writer's cramp
DOI: 10.1002/mds.21219
Keywords: writer's cramp, repetitive transcranial magnetic stimulation, short-latency afferent inhibition, somatosensory cortex, maladaptive plasticity, HUMAN MOTOR CORTEX, LOW-FREQUENCY RTMS, LATERAL PREMOTOR CORTEX, FOCAL HAND DYSTONIA, SOMATOSENSORY INPUT, RECIPROCAL INHIBITION, CORTICAL EXCITABILITY, GENERALIZED DYSTONIA, CERVICAL DYSTONIA, FOREARM MUSCLES
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/21095
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