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Optimization of the DCE-CT protocol using active imaging

Prevost, R; Buckley, DL; Alexander, DC; (2010) Optimization of the DCE-CT protocol using active imaging. In: 2010 7th IEEE International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2010 - Proceedings. (pp. 776 - 779). Green open access

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Abstract

This paper uses experiment design optimization to obtain the optimal placement of scans during dynamic contrast enhanced computed tomography. Here we construct and minimize an objective function based on the Cramer-Rao lower bound (CRLB) to optimize the accuracy of the estimators. Experiments based on simulated data are performed to compare our scheme with current sampling methods. Results reveal a significant reduction in error and variation of the fitted parameters while simultaneously reducing the number of scans, and thus the radiation dose received by the patient. We also show that our acquisition scheme is robust to the parameter values, easily adaptable to various parts of the body and therefore has great clinical potential. © 2010 IEEE.

Type: Proceedings paper
Title: Optimization of the DCE-CT protocol using active imaging
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/ISBI.2010.5490059
UCL classification: UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/19889
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