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Electrophysiological correlates of audio-visual integration of spoken words in typical development and autism spectrum disorder

Megnin, O.; (2010) Electrophysiological correlates of audio-visual integration of spoken words in typical development and autism spectrum disorder. Doctoral thesis, UCL (University College London).

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Abstract

This thesis examined audio-visual (AV) integration effects in speech processing using event-related potentials (ERP) in healthy adults, adolescents and children. In a further study ERP recordings in adolescent boys with autistic spectrum disorder were compared to matched typically developing boys. ERP effects were examined in three post-stimulus time windows: the N1 time window as a measure of sensitivity to word onset; the P2 as a measure of transition from phonetic to lexical-semantic processing; and the N4 as a measure of semantic processing. Participants were presented with monosyllabic words in four conditions: auditory-only, visualonly, audio-visual with face, and audio-visual with scrambled face. The study reports on the modulation of ERP due to such multimodal interactions between visual and auditory input, its developmental trajectory and evidence for disruption in ASD.

Type:Thesis (Doctoral)
Title:Electrophysiological correlates of audio-visual integration of spoken words in typical development and autism spectrum disorder
Language:English
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health

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