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QUANTITATION OF A MITOCHONDRIAL-DNA DELETION IN PARKINSONS-DISEASE

MANN, VM; COOPER, JM; SCHAPIRA, AHV; (1992) QUANTITATION OF A MITOCHONDRIAL-DNA DELETION IN PARKINSONS-DISEASE. FEBS LETT , 299 (3) 218 - 222.

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Abstract

A 5 kilobase deletion in mitochondrial DNA (mtDNA) has been reported to be responsible for the specific complex I deficiency in the substantia nigra (SN) of the Parkinson's disease (PD) brain. We have studied mitochondrial respiratory chain function in the SN from control and PD subjects, and analysed mtDNA, extracted from the same tissues, by Southern blot and the polymerase chain reaction (PCR). Quantitation of the levels of the deletion indicate that it does not contribute to the pathogenesis of PD nor to a complex I deficiency but seems likely to be an age-related observation.

Type: Article
Title: QUANTITATION OF A MITOCHONDRIAL-DNA DELETION IN PARKINSONS-DISEASE
Keywords: NADH COQ1 REDUCTASE, PARKINSONS DISEASE, MITOCHONDRION, MITOCHONDRIAL DNA, COMPLEX-I DEFICIENCY, NEUROTOXIN, METABOLITE, MYOPATHIES, STRIATUM, MUTATION, BRAIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/192492
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