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MITOCHONDRIAL-FUNCTION IN NEURODEGENERATION AND AGING

SCHAPIRA, AHV; COOPER, JM; (1992) MITOCHONDRIAL-FUNCTION IN NEURODEGENERATION AND AGING. MUTAT RES , 275 (3-6) 133 - 143.

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Abstract

The mitochondrial respiratory chain and oxidative phosphorylation system are responsible for the production of ATP by aerobic metabolism. Defects of the respiratory chain are increasingly recognised as important causes of human disease, and neurodegenerative disorders in particular. This article will seek to review the clinical and biochemical effects of respiratory chain defects, and summarise what is known about the molecular mechanisms that underlie them. Increasing age is also associated with a decline in mitochondrial function. The biochemical correlates of this dysfunction and the possible molecular defects that may cause it will also be reviewed.

Type: Article
Title: MITOCHONDRIAL-FUNCTION IN NEURODEGENERATION AND AGING
Keywords: MITOCHONDRIAL FUNCTION, RESPIRATORY CHAIN, NEURODEGENERATION, COMPLEX-I DEFICIENCY, HEREDITARY OPTIC NEUROPATHY, KEARNS-SAYRE SYNDROME, PARKINSONS-DISEASE, HUNTINGTONS-DISEASE, BRAIN MITOCHONDRIA, RESPIRATORY-CHAIN, TRANSFER RNALEU(UUR), LIPID-PEROXIDATION, MYOCLONIC EPILEPSY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/192487
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