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ANALYSES OF MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION AND MITOCHONDRIAL-DNA DELETION IN HUMAN SKELETAL-MUSCLE - EFFECT OF AGING

COOPER, JM; MANN, VM; SCHAPIRA, AHV; (1992) ANALYSES OF MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION AND MITOCHONDRIAL-DNA DELETION IN HUMAN SKELETAL-MUSCLE - EFFECT OF AGING. J NEUROL SCI , 113 (1) 91 - 98.

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Abstract

The analysis of human skeletal muscle mitochondria revealed a progressive decline in mitochondrial respiratory chain function with age. The activities affected to the greatest extent were those of complexes I and IV which were decreased by 59% and 47% respectively between the ages of 20-30 years and 60-90 years of age. Quantitation of the 5 kb 'common' deletion of mtDNA using PCR revealed a progressive accumulation with age, from approximately 1 in 100 000 at 21 years to 1 in 10 000 at 56 years and 1 in 5000 at 78 years of age. The low absolute levels of this mutation are unlikely to contribute significantly to the observed mitochondrial dysfunction.

Type: Article
Title: ANALYSES OF MITOCHONDRIAL RESPIRATORY-CHAIN FUNCTION AND MITOCHONDRIAL-DNA DELETION IN HUMAN SKELETAL-MUSCLE - EFFECT OF AGING
Keywords: MITOCHONDRIAL DYSFUNCTION, MITOCHONDRIAL DNA DELETION, HUMAN SKELETAL MUSCLE, AGING, COMPLEX-I DEFICIENCY, PARKINSONS-DISEASE, OXIDATIVE DAMAGE, INCREASE, STRIATUM, TISSUES, DECLINE, RAT
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: http://discovery.ucl.ac.uk/id/eprint/192485
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