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alpha-Synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone

Orth, M; Tabrizi, SJ; Schapira, AHV; Cooper, JM; (2003) alpha-Synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone. NEUROSCI LETT , 351 (1) 29 - 32. 10.1016/S0304-3940(03)00941-8.

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Abstract

Mitochondrial dysfunction has been implicated in the aetiology of sporadic Parkinson's disease but its role in the disease mechanism is not clear. We have investigated the short term effect of G209A mutant or wild-type a-synuclein expression upon mitochondrial function using stable inducible cell models. Mitochondrial respiratory chain activities and membrane potential were normal suggesting that increased wild-type or mutant alpha-synuclein expression did not directly affect these parameters. However, both wild-type and mutant G209A alpha-synuclein expression enhanced the fall in mitochondrial membrane potential induced by the complex I inhibitor rotenone. This suggests an indirect interaction between alpha-synuclein expression and mitochondrial function which could render the mitochondria more vulnerable to inhibition by potential endogenous or exogenous factors found in dopaminergic neurones. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

Type: Article
Title: alpha-Synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone
DOI: 10.1016/S0304-3940(03)00941-8
Keywords: alpha-synuclein, cell culture, Parkinson's disease, mitochondria, rotenone, complex I, mitochondrial membrane potential, PARKINSONS-DISEASE, ELECTRON-TRANSPORT, IN-VITRO, INVOLVEMENT, TOXICITY, MICE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/192410
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