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Antibody-directed enzyme prodrug therapy (ADEPT) for cancer

Bagshawe, KD; Sharma, SK; Begent, RHJ; (2004) Antibody-directed enzyme prodrug therapy (ADEPT) for cancer. EXPERT OPIN BIOL TH , 4 (11) 1777 - 1789. 10.1517/14712598.4.11.1777.

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Abstract

Antibody-directed enzyme prodrug therapy (ADEPT) aims to restrict the cytotoxic action to tumour sites. The obstacles to achieve this were recognised at the outset, but time and experience have given these better definition. The development of fusion proteins has provided the means of making consistent antibody-enzyme constructs on an adequate scale, and glycosylation has provided the means to control the clearance of enzyme from non-tumour sites. Human enzymes have yet to be tested in a clinical setting, and there are pointers indicating that the immunological response to foreign enzymes can be overcome. The relatively small number of purpose-designed prodrugs tested so far leaves this an area ripe for further development. The ongoing iterative process between preclinical and clinical studies is critical to achieving the objective.

Type: Article
Title: Antibody-directed enzyme prodrug therapy (ADEPT) for cancer
DOI: 10.1517/14712598.4.11.1777
Keywords: ADEPT, enzyme, fusion protein, prodrug, POLY(ETHYLENE GLYCOL) MODIFICATION, G AMIDASE CONJUGATE, IN-VIVO, BETA-LACTAMASE, FUSION PROTEIN, CARCINOEMBRYONIC ANTIGEN, SELECTIVE CHEMOTHERAPY, ANTICANCER PRODRUGS, CARBOXYPEPTIDASE G2, CYTOSINE DEAMINASE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: http://discovery.ucl.ac.uk/id/eprint/191748
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