Gladman, DD and Urowitz, MB and Goldsmith, CH and Fortin, P and Ginzler, E and Gordon, C and Hanly, JG and Isenberg, DA and Kalunian, K and Nived, O and Petri, M and SanchezGuerrero, J and Snaith, M and Sturfelt, G (1997) The reliability of the systemic Lupus International Collaborating Clinics American College of Rheumatology Damage Index in patients with Systemic Lupus Erythematosus. ARTHRITIS RHEUM , 40 (5) 809 - 813.
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Objective. To test the reliability of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology (SLICC/ACR) Damage Indes and the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) in the assessment of patients,vith SLE.Methods. Ten patients with SLE, representing a spectrum of damage and activity, were included, Each patient was examined by 6 of 10 physicians from 5 countries, representing 10 lupus clinics. The SLICC/ACR Damage Indes was used to assess accumulated damage, and the SLEDAI was used to assess disease activity, The order of the patients and physicians was randomized according to a Youden square design.Results. The SLICC/ACR Damage Index detected differences among patients (P <0.001). There was no detectable observer difference (P=0.933), and there was no order effect (P=0.261). Similar results were obtained with the SLEDAI. There was concordance in the SLICC/ACR Damage Index among observers, despite a wide spectrum of disease activity detected by the SLEDAI.Conclusion. Physicians from different centers are able to assess patients with SLE in a reproducible way, using the SLEDAI to assess disease activity and the SLICC/ACR Damage Index to assess accumulated damage.
|Title:||The reliability of the systemic Lupus International Collaborating Clinics American College of Rheumatology Damage Index in patients with Systemic Lupus Erythematosus|
|Keywords:||DISEASE-ACTIVITY INDEXES, VALIDATION, SLEDAI|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Inflammation|
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