Penny, WD;
Stephan, KE;
Daunizeau, J;
Rosa, MJ;
Friston, KJ;
Schofield, TM;
Leff, AP;
(2010)
Comparing Families of Dynamic Causal Models.
PLOS COMPUT BIOL
, 6
(3)
, Article e1000709. 10.1371/journal.pcbi.1000709.
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Abstract
Mathematical models of scientific data can be formally compared using Bayesian model evidence. Previous applications in the biological sciences have mainly focussed on model selection in which one first selects the model with the highest evidence and then makes inferences based on the parameters of that model. This "best model'' approach is very useful but can become brittle if there are a large number of models to compare, and if different subjects use different models. To overcome this shortcoming we propose the combination of two further approaches: (i) family level inference and (ii) Bayesian model averaging within families. Family level inference removes uncertainty about aspects of model structure other than the characteristic of interest. For example: What are the inputs to the system? Is processing serial or parallel? Is it linear or nonlinear? Is it mediated by a single, crucial connection? We apply Bayesian model averaging within families to provide inferences about parameters that are independent of further assumptions about model structure. We illustrate the methods using Dynamic Causal Models of brain imaging data.
| Type: | Article |
|---|---|
| Title: | Comparing Families of Dynamic Causal Models |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1371/journal.pcbi.1000709 |
| Publisher version: | http://dx.doi.org/10.1371/journal.pcbi.1000709 |
| Language: | English |
| Additional information: | © 2010 Penny et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by the Wellcome Trust. JD and KES also acknowledge support from Systems X, the Swiss Systems Biology Initiative and the University Research Priority Program “Foundations of Human Social Behavior” at the University of Zurich. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Keywords: | AUTOREGRESSIVE MODELS, BAYESIAN-ESTIMATION, VARIATIONAL BAYES, INFERENCE, SELECTION, SYSTEMS, INVERSE, PRIORS, FMRI |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience |
| URI: | https://discovery.ucl.ac.uk/id/eprint/191347 |
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