Pauleikhoff, D; Radermacher, M; Spital, G; Muller, C; Brumm, G; Lommatzsch, A; Bird, AC; (2002) Visual prognosis of second eyes in patients with unilateral late exudative age-related macular degeneration. Graefe's Archive for Clinical and Experimental Ophthalmology , 240 (7) 539 - 542.
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PURPOSE: A prospective longitudinal study was initiated to analyze the correlation between the prognosis for the second eyes of patients with unilateral late exudative AMD and the disease phenotype. METHODS: Of the187 patients with unilateral late exudative AMD recruited, 130 (69.5%) had predominantly classic CNV without pigment epithelium detachment (PED) (CNV group), and 57 (30.5%) had occult CNV with serous PED (PED group). Patients were reexamined by ophthalmoscopy and angiography every 6 months for up to 80 months. The end point was ETDRS visual acuity change of 3 lines or more due to late AMD in the second eye. RESULTS: During follow-up 53 (28.3%) patients reached the end point: 32 (24.6%) in the CNV group and 21 (36.8%) in the PED group. The major prognostic factor for the risk of visual loss in the second eye was the type of late AMD in the first eye (CNV group 6-7% per year, PED group 15-16% per year ( P<0.001). There was significant symmetry between the new exudative lesion in the second eye and that in the first, and significant differences in the density and fluorescence of drusen in the second eye between the two groups. CONCLUSIONS: Patients with occult CNV with serous PED in the first eye have a significantly higher risk of visual loss in the second eye than patients with CNV without PED. This distinction may be important for future clinical studies. In addition, segregation of AMD by phenotype is necessary in the analysis of genes conferring risk of AMD
|Title:||Visual prognosis of second eyes in patients with unilateral late exudative age-related macular degeneration|
|Additional information:||UI - 22131502 DA - 20020723 IS - 0721-832X LA - eng PT - Journal Article SB - IM|
|Keywords:||Aged, Aged, 80 and over, analysis, Choroidal Neovascularization, clinical, Clinical studies, Clinical study, CNV, complications, Correlation, DEGENERATION, DENSITIES, DENSITY, difference, disease, distinction, END, EPITHELIA, Epithelium, etiology, Exudates and Transudates, Eye, Female, Fluorescence, FOLLOW UP, Follow-up, Follow-Up Studies, future, GENE, Genes, groups, IM, LA, lesion, LINE, LINES, Longitudinal, Longitudinal Studies, longitudinal study, loss, Macular Degeneration, Male, May, Methods, Middle Age, ophthalmology, Ophthalmoscopy, Patient, patients, Phenotype, physiology, physiopathology, PIGMENT EPITHELIUM, Prognosis, prognostic, Prospective Studies, Result, Risk, segregation, SYMMETRY, Vision Disorders, visual, visual acuity|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology|
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