Parker, GJM and Stephan, KE and Barker, GJ and Rowe, JB and MacManus, DG and Wheeler-Kingshott, CAM and Ciccarelli, O and Passingham, RE and Spinks, RL and Lemon, RN and Turner, R (2002) Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor Imaging and fast marching tractography. NEUROIMAGE , 15 (4) 797 - 809. 10.1006/nimg.2001.0994.
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Diffusion tensor imaging (DTI), a magnetic resonance imaging technique, is used to infer major axonal projections in the macaque and human brain. This study investigates the feasibility of using known macaque anatomical connectivity as a "gold-standard" for the evaluation of DTI tractography methods. Connectivity information is determined from the DTI data using fast marching tractography (FMT), a novel tract-tracing (tractography) method. We show for the first time that it is possible to determine, in an entirely noninvasive manner, anatomical connection pathways and maps of an anatomical connectivity metric in the macaque brain using a standard clinical scanner and that these pathways are consistent with known anatomy. Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed. (C) 2002 Elsevier Science (USA).
|Title:||Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor Imaging and fast marching tractography|
|Keywords:||diffusion tensor imaging, tractography, macaque, anatomical connectivity, WALLERIAN DEGENERATION, VISUAL-SYSTEM, MRI, PATHWAYS, SCHIZOPHRENIA, ORGANIZATION, ANISOTROPY, TRACKING, CORTEX, AREAS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Brain Repair and Rehabilitation|
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > IoN - Neuroinflammation
UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Neurology > Motor Neuroscience and Movement Disorders
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