Iozzo, P and Chareonthaitawee, P and Di Terlizzi, M and Betteridge, DJ and Ferrannini, E and Camici, PG (2002) Regional myocardial blood flow and glucose utilization during fasting and physiological hyperinsulinemia in humans. AM J PHYSIOL-ENDOC M , 282 (5) E1163 - E1171. 10.1152/ajpendo.00386.2001.
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We investigated the effect of insulin on total and regional myocardial blood flow (MBF) and glucose uptake (MGU) in healthy subjects (50 +/- 5 yr) by means of positron emission tomography (PET) with oxygen-15-labeled water ((H2O)-O-15) and fluorine-18 labeled fluorodeoxyglucose ((18)FDG) before and during physiological hyperinsulinemia (40 mU.min(-1).m(-2)). Twelve male subjects were included in the study. During hyperinsulinemia, MBF increased from 0.91 +/- 0.28 to 1.01 +/- 0.31 ml.min(-1).g(-1) (n = 7 patients, P = 0.05; n = 112 regions, P < 0.005). Intersubject variability ranged from -3.0 to +41%. MGU increased from 0.11 +/- 0.08 (n = 5) to 0.56 +/- 0.08 mu mol.min(-1).g(-1) (P < 0.0001, n = 7). MBF and insulin-mediated MGU were higher in the septum and anterior and lateral wall along short-axis regions of the heart. During hyperinsulinemia, MBF was also higher in the apex and midventricle compared with the base. MBF and MGU were positively correlated before (r = 0.66, P < 0.0001) and during hyperinsulinemia (r = 0.24, P < 0.05). These results provide evidence that insulin stimulates MBF in normal human hearts and appears to involve mainly those regions of the heart where insulin-mediated MGU is higher. Furthermore, regional distribution of insulin-stimulated MBF and MGU does not appear to be uniform across the left ventricular wall of healthy subjects.
|Title:||Regional myocardial blood flow and glucose utilization during fasting and physiological hyperinsulinemia in humans|
|Keywords:||insulin, positron emission tomography, diabetes mellitus, POSITRON-EMISSION-TOMOGRAPHY, LEFT-VENTRICULAR DYSFUNCTION, DEPENDENT DIABETES-MELLITUS, CORONARY-ARTERY-DISEASE, SKELETAL-MUSCLE, INSULIN-RESISTANCE, HEART-DISEASE, METABOLISM, TRANSPORT, VASODILATION|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Metabolism and Experimental Therapeutics|
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