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Sarcopenia and hypertrophy: A role for insulin-like growth factor-1 in aged muscle?

Hameed, M; Harridge, SDR; Goldspink, G; (2002) Sarcopenia and hypertrophy: A role for insulin-like growth factor-1 in aged muscle? EXERC SPORT SCI REV , 30 (1) 15 - 19.

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Abstract

Sarcopenia is the loss of muscle mass associated with the aging process. Although systemic or circulating growth hormone and insulin-like growth factor-1 levels fall as we age, this is likely to be of lesser importance in regard to muscle mass than the rule of locally produced insulin-like growth factor-Is generated in the muscle in response to exercise.

Type:Article
Title:Sarcopenia and hypertrophy: A role for insulin-like growth factor-1 in aged muscle?
Keywords:muscle, strength, growth factors, aging, protein synthesis, MYOSIN HEAVY-CHAIN, SKELETAL-MUSCLE, GENE-EXPRESSION, IGF-I, PROTEIN, OLD, HORMONE, STRETCH, MEN
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of)

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