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Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents

Povey, A; Guppy, MJ; WOOD, M; Knight, C; Black, CM; Silman, AJ; (2001) Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents. Arthritis and Rheumatism , 44 (3) 662 - 665.

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Abstract

OBJECTIVE: To determine whether there are specific cytochrome P450 (CYP2) alleles that increase susceptibility to scleroderma in individuals who have been exposed to organic solvents. METHODS: CYP alleles at 2 loci, 2E1 and 2C19, were compared in 7 patients who had developed scleroderma after exposure to solvents versus 71 patients with scleroderma without solvent exposure ("sporadic" disease) and 106 population controls. RESULTS: The 2E1*3 allele was found in 2 of the 7 patients who had been exposed to organic solvents, with a greater frequency than occurred in either the disease controls or the population controls (odds ratio [95% confidence interval] 9.1 [1.5- 59.1] and 10.2 [1.8-62.2], respectively). All 7 patients with solvent exposure carried the 2C19EM genotype, compared with 89% of patients with sporadic scleroderma. CONCLUSION: Our results suggest that alleles at CYP loci may be involved in increasing susceptibility to scleroderma among subjects who have been exposed to organic solvents

Type:Article
Title:Cytochrome P2 polymorphisms and susceptibility to scleroderma following exposure to organic solvents
Additional information:UI - 21161193 LA - eng RN - 0 (Solvents) RN - 9035-51-2 (Cytochrome P-450) PT - Journal Article DA - 20010323 IS - 0004-3591 SB - AIM SB - IM CY - United States
Keywords:ALCOHOLIC LIVER-DISEASE, Allele, Alleles, Arthritis, confidence, control, CYP2E1, cytochrome P450, DEVELOPED, disease, Disease Control, English, EXPOSURE, FREQUENCIES, FREQUENCY, genetic polymorphisms, Genotype, HUMANS, INCREASE, individuals, LOCI, May, metabolism, Methods, NEW-YORK, objective, Odds Ratio, organic solvents, Patient, patients, Polymorphism, polymorphisms, population, RATIO, Result, Risk, SCLERODERMA, Solvents, SUSCEPTIBILITY, SYSTEMIC-SCLEROSIS, USA, adverse effects, Case-Control Studies, chemically induced, Comparative Study, Cytochrome P-450, Disease Susceptibility, Environmental Exposure, genetics, IM, LA, Polymorphism (Genetics), Scleroderma, Systemic, STATE, STATES, Support, Non-U.S.Gov't, united, United States, UNITED-STATES
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)

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