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Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus

Rolfe, KJ; Eva, LJ; Maclean, AB; Crow, JC; Perrett, CW; Reid, WMN; (2001) Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER , 11 (2) 113 - 118.

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Abstract

Lichen sclerosus (LS) has a known association with the development of squamous cell carcinoma of the vulva. The purpose of this study was to investigate molecular markers, which could indicate premalignant changes. Multiple sequential Vulvar biopsies were taken over a period of II years from a patient with longstanding LS. Immunohistochemical staining was used to demonstrate a range of molecular markers.Increased expression of p53 and Ki67 was found in areas of squamous hyperplasia (SH) and differentiated vulvar intraepithelial neoplasia (dVIN) which correlated with the subsequent development of invasive squamous cell carcinoma (SCC). Molecular changes have been found to accompany histologic changes in the progression of vulvar LS to malignancy. Such markers may prove a useful addition in the clinical management of these conditions.

Type: Article
Title: Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus
Location: OXFORD, ENGLAND
Keywords: histology, Ki67, p53, premalignant, squamous cell carcinoma, vulva, HISTOLOGICAL FEATURES, NUCLEAR ANTIGEN, ET-ATROPHICUS, P53, EXPRESSION, CARCINOMA, ADJACENT, BENIGN, KI-67, KI67
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Pathology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Inst for Women's Health > Maternal and Fetal Medicine
URI: http://discovery.ucl.ac.uk/id/eprint/190125
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