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Experimental verification and optimisation of a detailed dynamic high performance liquid chromatography column model

Teoh, HK; Turner, M; Titchener-Hooker, N; Sorensen, E; (2001) Experimental verification and optimisation of a detailed dynamic high performance liquid chromatography column model. COMPUTERS & CHEMICAL ENGINEERING , 25 (4-6) 893 - 903.

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Abstract

Detailed mathematical models of chromatographic separation processes is of crucial importance due to the increased application of this separation technique in the downstream processes of the biotechnological, pharmaceutical and fine chemical industries. In this paper, a detailed dynamic model of a high performance liquid chromatographic unit was experimentally verified and used as the basis for the optimisation of a preparative chromatographic separation using closed-loop recycling operation. Results confirmed that the effective column length could be increased by as much as 200% by recycling the feed sample back to the column for further purification with a concomitant improvement in purity and yield of the process. Data is presented to show the limitations of the method and the influence of key variables on column performance. Q 2001 Elsevier Science Ltd. All rights reserved.

Type: Article
Title: Experimental verification and optimisation of a detailed dynamic high performance liquid chromatography column model
Location: FLORENCE, ITALY
Keywords: chromatographic separation, recycling chromatographic operation, equilibrium-dispersive model, dynamic modelling and optimisation, PREPARATIVE CHROMATOGRAPHY, PATH CONSTRAINTS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Engineering Science Faculty Office
URI: http://discovery.ucl.ac.uk/id/eprint/189973
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