UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Non-invasive measurement of biomechanical skin properties in systemic sclerosis.

Balbir-Gurman, A; Denton, CP; Nichols, B; Knight, CJ; Nahir, AM; Martin, G; Black, CM; (2002) Non-invasive measurement of biomechanical skin properties in systemic sclerosis. Ann Rheum Dis , 61 (3) pp. 237-241. 10.1136/ard.61.3.237.

Full text not available from this repository.

Abstract

OBJECTIVE: To evaluate biomechanical properties of skin in patients with systemic sclerosis (SSc) using the BTC-2000 suction device. METHODS: Twenty five patients with limited cutaneous SSc (lcSSc), 20 patients with diffuse disease (dcSSc), and 25 age matched healthy controls were evaluated. Viscoelastic deformation (VED, mm), elastic deformation (ED, mm), ultimate deformation (UD, mm), and pressure-deformation ratio (PDR, mm Hg/mm) were measured on the dorsal surface of the forearm, shoulder, and above the trapezius muscle on the back. RESULTS: Indices of skin extensibility (VED, ED, UD) were reduced and resistance to stress (PDR) increased in patients with dcSSc compared with healthy controls, or patients with lcSSc, at all three sites (p<0.001). At all sites, and overall, UD, ED, and VED were lower and PDR was higher at skin score above grade 2, compared with clinically normal skin. For both lcSSc and dcSSc biomechanical differences from controls were found even at sites of clinically normal skin. CONCLUSION: BTC-2000 is a sensitive tool for clinical evaluation of skin involvement in SSc and may be a valuable adjunct to skin sclerosis score in disease monitoring.

Type: Article
Title: Non-invasive measurement of biomechanical skin properties in systemic sclerosis.
Location: England
DOI: 10.1136/ard.61.3.237
Keywords: Adult, Aged, Analysis of Variance, Biomechanical Phenomena, Case-Control Studies, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Normal Distribution, Scleroderma, Systemic, Skin, Statistics, Nonparametric, Vacuum
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation
URI: http://discovery.ucl.ac.uk/id/eprint/189945
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item