Coating stent materials with polyhedral oligomeric silsesquioxane-poly(carbonateurea)urethane nanocomposites.
Doctoral thesis, UCL (University College London).
The long-term efficacy of coronary or peripheral stenting is limited by in-stent restenosis (ISR), which occurs in 15 to 30% of patients and is attributed primarily to neointimal hyperplasia. By adding a drug-eluting coating, this rate has been reduced to about 5% or less. However, recently longer-term follow-up data has highlighted problems with drug-coated stents, including late stage thrombosis. A bio-stable poly(carbonate-urea)urethane has been used for stent coating and the surface properties of the polymer have been optimised by incorporating the polyhedral oligomeric silsesquioxane molecule. These POSS polymers improve the adhesion and the growth of endothelial cells. The work described in this thesis, presents an innovative approach in self-expanding/balloon expandable coronary stent design that incorporates a NiTi/stainless steel alloy scaffold with a polyhedral oligomeric silsesquioxane- poly (carbonate-urea) urethane nanocomposite polymer (POSS-PCU) coating. Electrohydrodynamic spraying and ultrasonic atomization spraying of the non-biodegradable nanocomposite polyhedral oligomeric silsesquioxane (POSS) polymer have been investigated in detail for coating metallic stent materials and compared with dip coating. Because of the tight geometry of coronary stents, these new coating techniques have been shown to offer advantages over traditional coating techniques. These advantages include, reduced polymer consumption, precise coating thickness as low as 10 μm and a highly controllable spray which leads to consistent reproducible results. However, poor adhesion, or bond deterioration over the lifespan/ deployment of the device could reduces the efficiency and could impart even more complexity to the implant including formation of debris which can induce thrombus formation. Changing the surface physical property/chemical composition through the proposed protocol has been shown to increase the bonding strength by up to three times. This study has identified a new process and conditions which can be used in stent coating research.
|Title:||Coating stent materials with polyhedral oligomeric silsesquioxane-poly(carbonateurea)urethane nanocomposites|
|Open access status:||An open access version is available from UCL Discovery|
|UCL classification:||UCL > School of BEAMS > Faculty of Engineering Science > Mechanical Engineering|
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