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Genome scans and candidate gene approaches in the study of common diseases and variable drug responses

Goldstein, DB; Ahmadi, KR; Weale, ME; Wood, NW; (2003) Genome scans and candidate gene approaches in the study of common diseases and variable drug responses. TRENDS GENET , 19 (11) 615 - 622. 10.1016/j.tig.2003.09.006.

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Abstract

There is both tremendous enthusiasm and controversy surrounding genetic association studies. In this article we use new methods for representing variation in the human genome that suggest as a few as 170 000 carefully selected single nucleotide polymorphisms (SNPs) are sufficient to represent all the common SNPs in European or East Asian population samples, and up to 300 000 in West African population samples. We also show that efficient genome scans require a detailed description of genomic variation in humans, as envisioned in the HapMap project. Although these analyses are encouraging about the prospects for genome scans, we argue that the difficulty of fine-localization of causal variants will be an important obstacle to progress, and that for reasons of both cost and statistical power candidate gene approaches are likely to remain the primary focus of genetic association studies for years to come.

Type: Article
Title: Genome scans and candidate gene approaches in the study of common diseases and variable drug responses
DOI: 10.1016/j.tig.2003.09.006
Keywords: LINKAGE-DISEQUILIBRIUM, HAPLOTYPE BLOCKS, POPULATION STRATIFICATION, ASSOCIATION, SNPS, PHARMACOGENETICS, SUSCEPTIBILITY, IDENTIFICATION, TRAITS, HUMANS
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: http://discovery.ucl.ac.uk/id/eprint/189790
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