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Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy

de Silva, R; Hope, A; Pittman, A; Weale, ME; Morris, HR; Wood, NW; Lees, AJ; (2003) Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy. NEUROLOGY , 61 (3) 407 - 409.

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Abstract

Recent reports are inconclusive in showing that the Q7R polymorphism of the novel Saitohin gene, nested in intron 9 of the tau gene, is associated with AD. The authors show that this polymorphism is in complete linkage disequilibrium with the extended tau H1/H2 haplotype and that the Q variant and QQ genotype of Q7R are strongly associated with progressive supranuclear palsy, implicating it as a possibly important pathogenic candidate.

Type: Article
Title: Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy
Keywords: ALZHEIMERS-DISEASE, TAU GENE, NEURODEGENERATIVE DISEASES, POLYMORPHISM, HAPLOTYPE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: http://discovery.ucl.ac.uk/id/eprint/189732
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