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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.
Genetic variation in NOD2 has been associated with susceptibility to Crohn's disease (CD) and specifically with ileal involvement. The reason for the unique association of NOD2 mutations with ileal disease is unclear. To identify a possible link, we tested expression of NOD2 in intestinal tissue of CD patients and controls.
|Title:||Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis.|
|Keywords:||Adolescent, Adult, Aged, Antibodies, Monoclonal, Carrier Proteins, Colitis, Ulcerative, Colon, Crohn Disease, Female, Gene Expression Regulation, Humans, Ileum, Immunoblotting, Immunohistochemistry, Intracellular Signaling Peptides and Proteins, Male, Metaplasia, Middle Aged, Nod2 Signaling Adaptor Protein, Paneth Cells, Precipitin Tests, RNA, Messenger, Reverse Transcriptase Polymerase Chain Reaction|
|UCL classification:||UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
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