Renzoni, EA and Walsh, DA and Salmon, M and Wells, AU and Sestini, P and Nicholson, AG and Veeraraghavan, S and Bishop, AE and Romanska, HM and Pantelidis, P and Black, CM and du Bois, RM (2003) Interstitial vascularity in fibrosing alveolitis. American Journal of Respiratory and Critical Care Medicine , 167 (3) 438 - 443.
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The aim of this study was to evaluate interstitial vascularity in cryptogenic fibrosing alveolitis (CFA) and in fibrosing alveolitis associated with systemic sclerosis (FASSc). Open lung biopsies from eight patients with CFA, nine patients with FASSc, and normal lung from 12 patients undergoing surgery for lung cancer were studied. Markers for endothelial cells (CD34) and cell proliferation (proliferating cell nuclear antigen) were localized by sequential immunohistochemistry and quantified using computer-assisted analysis. Vascular distribution was evaluated at increasing distances (up to 160 microm) from the airspaces. Vessel density was markedly reduced in both FASSc (3.9%) and in CFA (4.5%) compared with control samples (20.4%, p < 0.0001). The percentage of tissue occupied by vessels decreased with increasing distance from alveoli in control samples but not in CFA or FASSc samples. Endothelial cell proliferation indices were increased in FASSc but not in CFA, compared with control samples (p = 0.006). In conclusion, there is net vascular ablation and redistribution of blood vessels in areas of interstitial thickening in both CFA and FASSc, which may contribute to gas exchange impairment
|Title:||Interstitial vascularity in fibrosing alveolitis|
|Additional information:||DA - 20030129 IS - 1073-449X LA - eng PT - Journal Article RN - 0 (Proliferating Cell Nuclear Antigen) SB - AIM SB - IM|
|Keywords:||adult, Aged, analysis, ANTIGEN, Biopsy, Blood, Blood Gas Analysis, blood supply, blood vessel, blood vessels, BLOOD-VESSELS, cancer, CD34, cell, Cell Proliferation, CELL-PROLIFERATION, CELLS, chemistry, Computer assisted, control, DENSITIES, DENSITY, Distance, distribution, Endothelial, endothelial cell, endothelial cells, ENDOTHELIAL-CELLS, Endothelium, Female, GAS, IM, Immunohistochemistry, IMPAIRMENT, Indices, Interstitial, LA, Lung, Lung cancer, LUNG-CANCER, Male, MARKER, Markers, May, Middle Aged, Neovascularization, Pathologic, nuclear, NUCLEAR ANTIGEN, pathology, Patient, patients, PERCENTAGE, Proliferating Cell Nuclear Antigen, proliferation, Pulmonary Alveoli, Pulmonary Fibrosis, SAMPLE, SAMPLES, SCLEROSIS, surgery, SYSTEMIC, SYSTEMIC SCLEROSIS, Tissue, vascular, VASCULARITY, vessels|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)|
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