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Comparative genomic and phylogeographic analysis of Mycobacterium leprae

Monot, M; Honore, N; Garnier, T; Zidane, N; Sherafi, D; Paniz-Mondolfi, A; ... Cole, ST; + view all (2009) Comparative genomic and phylogeographic analysis of Mycobacterium leprae. NAT GENET , 41 (12) 1282 - U39. 10.1038/ng.477. Green open access

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Abstract

Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6 x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38 x coverage) and NHDP63 (46 x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.

Type:Article
Title:Comparative genomic and phylogeographic analysis of Mycobacterium leprae
Open access status:An open access version is available from UCL Discovery
DOI:10.1038/ng.477
Keywords:NUMBER TANDEM REPEATS, HELICOBACTER-PYLORI, LEPROSY PATIENTS, YERSINIA-PESTIS, CAUSATIVE AGENT, BURULI ULCER, TUBERCULOSIS, SEQUENCE, EVOLUTION, POPULATIONS
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of) > Research Department of Infection

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