Monot, M; Honore, N; Garnier, T; Zidane, N; Sherafi, D; Paniz-Mondolfi, A; ... Cole, ST; + view all Monot, M; Honore, N; Garnier, T; Zidane, N; Sherafi, D; Paniz-Mondolfi, A; Matsuoka, M; Taylor, GM; Donoghue, HD; Bouwman, A; Mays, S; Watson, C; Lockwood, D; Khamispour, A; Dowlati, Y; Shen, JP; Rea, TH; Vera-Cabrera, L; Stefani, MM; Banu, S; Macdonald, M; Sapkota, BR; Spencer, JS; Thomas, J; Harshman, K; Singh, P; Busso, P; Gattiker, A; Rougemont, J; Brennan, PJ; Cole, ST; - view fewer (2009) Comparative genomic and phylogeographic analysis of Mycobacterium leprae. NAT GENET , 41 (12) 1282 - U39. 10.1038/ng.477.
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Reductive evolution and massive pseudogene formation have shaped the 3.31-Mb genome of Mycobacterium leprae, an unculturable obligate pathogen that causes leprosy in humans. The complete genome sequence of M. leprae strain Br4923 from Brazil was obtained by conventional methods (6 x coverage), and Illumina resequencing technology was used to obtain the sequences of strains Thai53 (38 x coverage) and NHDP63 (46 x coverage) from Thailand and the United States, respectively. Whole-genome comparisons with the previously sequenced TN strain from India revealed that the four strains share 99.995% sequence identity and differ only in 215 polymorphic sites, mainly SNPs, and by 5 pseudogenes. Sixteen interrelated SNP subtypes were defined by genotyping both extant and extinct strains of M. leprae from around the world. The 16 SNP subtypes showed a strong geographical association that reflects the migration patterns of early humans and trade routes, with the Silk Road linking Europe to China having contributed to the spread of leprosy.
|Title:||Comparative genomic and phylogeographic analysis of Mycobacterium leprae|
|Open access status:||An open access version is available from UCL Discovery|
|Keywords:||NUMBER TANDEM REPEATS, HELICOBACTER-PYLORI, LEPROSY PATIENTS, YERSINIA-PESTIS, CAUSATIVE AGENT, BURULI ULCER, TUBERCULOSIS, SEQUENCE, EVOLUTION, POPULATIONS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of)|
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