Matheson, CD; Vernon, KK; Lahti, A; Fratpietro, R; Spigelman, M; Gibson, S; ... Donoghue, HD; + view all Matheson, CD; Vernon, KK; Lahti, A; Fratpietro, R; Spigelman, M; Gibson, S; Greenblatt, CL; Donoghue, HD; - view fewer (2009) Molecular Exploration of the First-Century Tomb of the Shroud in Akeldama, Jerusalem. PLOS ONE , 4 (12) , Article e8319. 10.1371/journal.pone.0008319.
|PDF - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader|
The Tomb of the Shroud is a first-century C. E. tomb discovered in Akeldama, Jerusalem, Israel that had been illegally entered and looted. The investigation of this tomb by an interdisciplinary team of researchers began in 2000. More than twenty stone ossuaries for collecting human bones were found, along with textiles from a burial shroud, hair and skeletal remains. The research presented here focuses on genetic analysis of the bioarchaeological remains from the tomb using mitochondrial DNA to examine familial relationships of the individuals within the tomb and molecular screening for the presence of disease. There are three mitochondrial haplotypes shared between a number of the remains analyzed suggesting a possible family tomb. There were two pathogens genetically detected within the collection of osteological samples, these were Mycobacterium tuberculosis and Mycobacterium leprae. The Tomb of the Shroud is one of very few examples of a preserved shrouded human burial and the only example of a plaster sealed loculus with remains genetically confirmed to have belonged to a shrouded male individual that suffered from tuberculosis and leprosy dating to the first-century C.E. This is the earliest case of leprosy with a confirmed date in which M. leprae DNA was detected.
|Title:||Molecular Exploration of the First-Century Tomb of the Shroud in Akeldama, Jerusalem|
|Open access status:||An open access publication. A version is also available from UCL Discovery.|
|Additional information:||© 2009 Matheson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
|Keywords:||POLYMERASE-CHAIN-REACTION, MYCOBACTERIUM-LEPRAE DNA, HUMAN SKELETAL REMAINS, ANCIENT DNA, MITOCHONDRIAL-DNA, MTDNA SEQUENCE, TUBERCULOSIS, LEPROSY, IDENTIFICATION, PCR|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
View download statistics for this item
Activity - last month
Activity - last 12 months
Archive Staff Only: edit this record