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Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo

Tofts, PS; Lloyd, D; Clark, CA; Barker, GJ; Parker, GJM; McConville, P; Baldock, C; (2000) Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo. MAGN RESON MED , 43 (3) 368 - 374.

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Abstract

A range of liquids suitable as quality control test objects for measuring the accuracy of clinical MRI diffusion sequences (both apparent diffusion coefficient and tensor) has been identified and characterized. The self-diffusion coefficients for 15 liquids (3 cyclic alkanes: cyclohexane to cyclooctane, 9 n-alkanes: n-octane to n-hexadecane, and 3 n-alcohols: ethanol to 1-propanol) were measured at 15-30 degrees C using an NMR spectrometer. Values at 22 degrees C range from 0.36 to 2.2 10(-9) m(2)s(-1). Typical 95% confidence limits are +/-2%. Temperature coefficients are 1.7-3.2 %/degrees C. T-1 and T-2 values at 1.5 T and proton density are given. n-tridecane has a diffusion coefficient close to that of normal white matter. The longer n-alkanes may be useful T-2 standards. Measurements from a spin-echo MRI sequence agreed to within 2%. (C) 2000 Wiley-Liss, Inc.

Type: Article
Title: Test liquids for quantitative MRI measurements of self-diffusion coefficient in vivo
Keywords: diffusion coefficient, MRI, alkane, quality control, HUMAN BRAIN, SPIN-ECHO, TENSOR, SPECTROSCOPY, ANISOTROPY, STROKE
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/188293
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