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A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.

Ruperto, N; Murray, KJ; Gerloni, V; Wulffraat, N; de Oliveira, SK; Falcini, F; Dolezalova, P; (2004) A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate. Arthritis Rheum , 50 (7) pp. 2191-2201. 10.1002/art.20288.

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Abstract

To compare the safety and efficacy of parenteral methotrexate (MTX) at an intermediate dosage (15 mg/m(2)/week) versus a higher dosage (30 mg/m(2)/week) in patients with polyarticular-course juvenile idiopathic arthritis (JIA) who failed to improve while receiving standard dosages of MTX (8-12.5 mg/m(2)/week).

Type: Article
Title: A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate.
Location: United States
DOI: 10.1002/art.20288
Keywords: Antirheumatic Agents, Arthritis, Juvenile, Child, Child, Preschool, Dose-Response Relationship, Drug, Female, Humans, Infusions, Parenteral, Male, Methotrexate, Treatment Outcome
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Infection and Immunity (Division of)
URI: http://discovery.ucl.ac.uk/id/eprint/188231
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