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THE THEORETICAL BASIS FOR THE DETERMINATION OF OPTICAL PATHLENGTHS IN TISSUE - TEMPORAL AND FREQUENCY-ANALYSIS

ARRIDGE, SR; COPE, M; DELPY, DT; (1992) THE THEORETICAL BASIS FOR THE DETERMINATION OF OPTICAL PATHLENGTHS IN TISSUE - TEMPORAL AND FREQUENCY-ANALYSIS. PHYS MED BIOL , 37 (7) 1531 - 1560.

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Abstract

A concise theoretical treatment is developed for the calculation of mean time, differential pathlength, phase shift, modulation depth and integrated intensity of measurements of light intensity as a function of time on the surface of tissue, resulting from either the input of picosecond light pulses, or radio frequency-modulated light. The treatment uses the Green's function of the diffusion approximation to the radiative transfer equation, and develops this and its Fourier transform in a variety of geometries. Detailed comparisons are made of several of these parameters in several geometries, and their relation to experimentally measured clinical data. The limitations of the use of phase measurements is discussed.

Type:Article
Title:THE THEORETICAL BASIS FOR THE DETERMINATION OF OPTICAL PATHLENGTHS IN TISSUE - TEMPORAL AND FREQUENCY-ANALYSIS
Keywords:NEAR-INFRARED SPECTROSCOPY, NEWBORN-INFANTS, CEREBRAL OXYGENATION, TRANS-ILLUMINATION, MAMMALIAN-TISSUES, TIME, SYSTEM, HEMOGLOBIN, MUSCLE, BLOOD
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

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