Leung, TS;
Tachtsidis, I;
Tisdall, M;
Smith, M;
Delpy, DT;
Elwell, CE;
(2007)
Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus Indocyanine Green injection and near-infrared spectroscopy.
APPLIED OPTICS
, 46
(10)
1604 - 1614.
10.1364/AO.46.001604.
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Abstract
To investigate the accuracy of measuring cerebral blood flow (CBF) using a bolus injection of Indocyanine Green (ICG) detected by near-infrared spectroscopy in adult human heads, simulations were performed using a two-layered model representing the extracerebral and intracerebral layers. Modeled optical data were converted into tissue ICG concentration using either the one-detector modified Beer-Lambert law (MBLL) method, or the two-detector partial path-length (PPL) method. The CBFs were estimated using deconvolution and blood flow index techniques. Using the MBLL method, the CBFs were significantly underestimated but the PPL method improved their accuracy and robustness, especially when used as relative measures. The dispersion of the arterial input function also affected the CBF estimates. (c) 2007 Optical Society of America.
| Type: | Article |
|---|---|
| Title: | Theoretical investigation of measuring cerebral blood flow in the adult human head using bolus Indocyanine Green injection and near-infrared spectroscopy |
| Location: | Ft Lauderdale, FL |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1364/AO.46.001604 |
| Publisher version: | http://dx.doi.org/10.1364/AO.46.001604 |
| Additional information: | © 2007 Optical Society of America |
| Keywords: | NONINVASIVE MEASUREMENT, OPTICAL-PROPERTIES, DIFFUSE-REFLECTANCE, MAGNETIC-RESONANCE, NEWBORN PIGLETS, DYE DILUTION, TISSUE, BRAIN, HEMODYNAMICS, QUANTIFICATION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/187598 |
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