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MTR and TI provide complementary information in MS NAWM, but not in lesions

Griffin, CM; Parker, GJM; Barker, GJ; Tompson, AJ; Miller, DH; (2000) MTR and TI provide complementary information in MS NAWM, but not in lesions. MULT SCLER , 6 (5) 327 - 331.

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Abstract

MTR and TI relaxation times ore abnormal in MS lesions and NAWM, and may reflect tissue damage such as demyelination and axonal loss. Their relationship and potential to provide complementary information in tissue characterisation is explored The aim of this study was to document the relationship between magnetisation transfer ratio (MTR) and TI relaxation time in Multiple Sclerosis (MS) lesions and normal appearing white matter (NAWM) in order to determine whether the combination provides a more comprehensive tissue characterisation than either parameter in isolation. Ten Patients with relapsing remitting MS and la age matched healthy controls underwent imaging using a protocol which included the measurement of both MTR and TI relaxation times. The MTR and TI values were compared statistically using a commonly adopted correlation approach and a mixed-model regression approach. There was a strong correlation between MTR and TI in MS lesions (r=0.74). The correlation was seen equally in TI hypointense and isointense lesions. The relationship was much weaker in MS NAWM (r=0.24) and no correlation was found in control while matter (r=0.06). Mixed-model regression analysis confirmed that the relationship between TI and MTR is strongly dependent upon tissue type (MS lesion, MS NAWM, or control white matter). The relationship between MTR and TI relaxation time measurements varies markedly between Pathological and normal tissue types In MS, the complementary information obtained from MTR and TI is most apparent in NAWM. The results emphasise the Potential for combinations of MR parameters to improve tissue characterisation, which in turn should improve understanding of disease pathology and treatment monitoring.

Type: Article
Title: MTR and TI provide complementary information in MS NAWM, but not in lesions
Keywords: multiple sclerosis, magnetisation transfer ratio, TI relaxation time, normal appearing white matter, MAGNETIZATION-TRANSFER RATIO, MULTIPLE-SCLEROSIS LESIONS, SPIN-ECHO IMAGES, DISEASE-ACTIVITY, WHITE-MATTER, DISABILITY, MRI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: http://discovery.ucl.ac.uk/id/eprint/187212
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