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Scleroderma and related disorders: therapeutic aspects

Denton, CP; Black, CM; (2000) Scleroderma and related disorders: therapeutic aspects. Best Practice and Research Clinical Rheumatology , 14 (1) pp. 17-35.

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Improvements in management of systemic sclerosis have occurred through a growing understanding of pathogenic events accompanied by advances in diagnosis and assessment, as well as developments in organ-based therapeutics. Unfortunately, disease-modifying therapies of proven efficacy remain elusive and several agents in current use have been shown in well-controlled clinical trials to be of questionable benefit. More positively, there have been advances in the treatment of major visceral complications such as renal crisis, pulmonary fibrosis, pulmonary hypertension, gastrointestinal involvement and in the management of scleroderma-associated Raynaud's phenomenon. Current approaches are reviewed, evidence supporting or refuting the use of putative disease-modifying agents is discussed, and new strategies are described that are currently being considered for this fascinating but complex multisystem connective tissue disease

Type: Article
Title: Scleroderma and related disorders: therapeutic aspects
Additional information: UI - 20338060 LA - eng PT - Journal Article PT - Review PT - Review, Tutorial DA - 20001012 IS - 1521-6942 SB - IM CY - ENGLAND JC - DHY
Keywords: advances, AGENTS, As, assessment, benefit, clinical, Clinical trial, Clinical Trials, COMPLEX, COMPLEXES, complications, development, diagnosis, disease, DISORDER, Disorders, EFFICACY, etiology, Fibrosis, Gastrointestinal, Gastrointestinal Diseases, Heart Diseases, Hypertension, INVOLVEMENT, Kidney Diseases, Lung Diseases, Management, Musculoskeletal Diseases, pulmonary, Pulmonary Fibrosis, Raynaud's Disease, renal, Review, Rheumatology, SCLERODERMA, Scleroderma, Systemic, SCLEROSIS, Skin Diseases, strategies, strategy, SYSTEMIC SCLEROSIS, therapeutic, therapy, Tissue, treatment, TRIAL, TRIALS, UK, Vascular Diseases
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences
URI: http://discovery.ucl.ac.uk/id/eprint/187153
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