Denton, CP and Bunce, TD and Darado, MB and Roberts, Z and Wilson, H and Howell, K and Bruckdorfer, KR and Black, CM (1999) Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon 5. Rheumatology , 38 (4) 309 - 315.
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OBJECTIVE: Reactive oxygen species have been implicated in the pathogenesis of inflammatory and vascular disease. We have undertaken a controlled trial to evaluate probucol, a synthetic antioxidant, as a potential therapy for Raynaud's phenomenon. METHODS: The study cohort included patients with systemic sclerosis (SSc; n = 20), primary Raynaud's phenomenon (n = 15) or 'autoimmune Raynaud's' (n = 5). Patients were allocated to receive either probucol (500 mg daily) or nifedipine (20 mg daily) for 12 weeks. Clinical and biochemical variables at baseline were compared with those at completion of treatment. Evaluation included assessment of Raynaud's attack frequency and severity by visual analogue scale, measurement of low-density lipoprotein (LDL) oxidation lag time, and plasma concentrations of cholesterol, triglyceride, vitamin E and vitamin C. RESULTS: There was a significant reduction of both the frequency and severity of Raynaud's attacks in the patients who received probucol, but not in the control group. LDL oxidation lag time, reflecting in vitro susceptibility to oxidation, was also increased by probucol therapy and serum cholesterol levels were significantly reduced. Similar changes were observed in both SSc-and non-SSc-associated Raynaud's cases. CONCLUSION: These data suggest that probucol may be useful for the symptomatic treatment of Raynaud's phenomenon and also reduces LDL oxidation susceptibility. Since oxidized lipoproteins may mediate vascular damage in SSc, the use of probucol could have additional disease-modifying benefits. Based upon the results of this pilot study, further evaluation of this novel form of therapy is warranted
|Title:||Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon 5|
|Additional information:||UI - 99305051 LA - Eng RN - 0 (oxidized low density lipoprotein) RN - 0 (Anticholesteremic Agents) RN - 0 (Antioxidants) RN - 0 (Lipoproteins) RN - 0 (Lipoproteins, LDL) RN - 0 (Triglycerides) RN - 0 (Vasodilator Agents) RN - 1406-18-4 (Vitamin E) RN - 21829-25-4 (Nifedipine) RN - 23288-49-5 (Probucol) RN - 50-81-7 (Ascorbic Acid) PT - CLINICAL TRIAL PT - JOURNAL ARTICLE PT -RANDOMIZED CONTROLLED TRIAL DA - 19990701 IS - 1462-0324 SB - M CY - ENGLAND JC - DDB AA - Author EM - 199909|
|Keywords:||Lipoproteins, Vasodilator Agents, Acids, administration & dosage, Anticholesteremic Agents, Antioxidants, Ascorbic Acid, blood, Cohort Studies, Comparative Study, drug therapy, In Vitro, Lipoproteins, LDL, metabolism, Methods, Nifedipine, Oxidation-Reduction, oxidized low density lipoprotein, Probucol, Raynaud's Disease, Reactive Oxygen Species, Scleroderma, Systemic, Support, Non-U.S.Gov't, Triglycerides, Vitamin E, vascular, plasma, control|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of)
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