Västrik, I; Eickholt, BJ; Walsh, FS; Ridley, A; Doherty, P; (1999) Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32. Curr Biol , 9 (18) 991 - 998.
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Neurons project their axons along specific pathways in order to establish appropriate connections with their target cells. The rate and direction of axonal growth is determined by interactions between the highly motile growth cone and environmental cues that can act in either an attractive or a repulsive manner. Locomotion is ultimately dependent upon the reorganisation of the actin cytoskeleton and an established role for the Rho family of small GTPases in regulating this process in non-neuronal cells identifies them as candidate signalling molecules in growth cones. An inactive form of Rac1 has recently been shown to inhibit the 'growth-cone collapse' response induced by chick Sema3A, a protein that has recently been established as an important guidance cue. The molecular basis for this inhibition remains unclear.
|Title:||Sema3A-induced growth-cone collapse is mediated by Rac1 amino acids 17-32.|
|Keywords:||Amino Acid Sequence, Animals, COS Cells, Carrier Proteins, Cercopithecus aethiops, Chick Embryo, GTPase-Activating Proteins, Glycoproteins, Growth Cones, Models, Molecular, Molecular Sequence Data, Peptide Fragments, Phosphatidylinositol 3-Kinases, Phosphoproteins, Protein Conformation, Protein Structure, Tertiary, Proteins, Recombinant Fusion Proteins, Semaphorin-3A, Sequence Alignment, Sequence Homology, Amino Acid, Wiskott-Aldrich Syndrome Protein, cdc42 GTP-Binding Protein, rac1 GTP-Binding Protein|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
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