Williams, R; (2006) The elusive goal of liver support – quest for the Holy Grail. Clinical Medicine , 6 (5) 482 - 487.
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ABSTRACT – The history of liver support devices is traced from early attempts with dialysis based on the known dialysability of ammonia – the major identified toxin in liver failure – and exchange transfusion with removal of proteinbound toxins, to the later techniques based on whole organ perfusion in extracorporeal circuits. Perfusion through charcoal as an adsorbent represented a major advance and remains a component of more recently introduced devices based on bioreactors of cultured hepatocytes and in the albumin dialysis techniques of molecular adsorbent recirculating system and the Prometheus device. The latter are the most highly efficient to date in toxin removal but whether survival is improved and the need for liver transplantation remain to be proven.
|Title:||The elusive goal of liver support – quest for the Holy Grail.|
|Keywords:||albumin dialysis, bioartificial devices, charcoal haemoperfusion, liver failure, water-soluble/protein-bound toxins|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Institute of Hepatology|
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