Loesch, A; Turmaine, M; Loizidou, M; Crowe, R; Ashraf, S; Taylor, I; Burnstock, G; (1997) Increase in immunoreactivity for endothelin-1 in blood vessels of rat liver metastases: experimental sarcoma and carcinoma. J Anat , 191 ( Pt 2) 291 - 299.
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Using electron immunocytochemistry, blood vessels in the normal rat liver and in 2 different animal models of liver metastases: (1) Hooded Lister rat with MC28 tumour, a sarcoma, and (2) nude rat with HT29 tumour, a carcinoma, were investigated for the presence of endothelin-1. In the normal livers, small subpopulations of vascular endothelial cells displayed discrete immunoreactivity for endothelin-1. In the livers with malignant tumours, there was a substantial increase in endothelin-1-immunoreactive endothelial cells in vessels located at the tumour periphery. In the controls, antibody to endothelin-1 also labelled sporadically some fibroblast/fibroblast-like cells associated with the blood vessels. In contrast, intense immunoreactivity for endothelin-1 was frequently associated with the tumour cells and/or fibroblast cells in both types of tumour examined.
|Title:||Increase in immunoreactivity for endothelin-1 in blood vessels of rat liver metastases: experimental sarcoma and carcinoma.|
|Additional information:||PMCID: PMC1467681|
|Keywords:||Animals, Carcinoma, Endothelin-1, Endothelium, Vascular, Fibroblasts, Liver, Liver Neoplasms, Experimental, Male, Microscopy, Immunoelectron, Rats, Rats, Inbred Strains, Rats, Nude, Sarcoma, Experimental|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)|
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Inflammation
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of) > Research Department of General Surgery
UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > UCL Medical School
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