UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus

Rogelj, B; Hartmann, CEA; Yeo, CH; Hunt, SP; Giese, KP; (2003) Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus. EUR J NEUROSCI , 18 (11) 3089 - 3096. 10.1046/j.1460-9568.2003.03026.x.

Full text not available from this repository.

Abstract

Some small nucleolar RNAs (snoRNAs) are exclusively expressed in the brain but they have no known role in higher brain function. We analysed the expression pattern of four brain-specific snoRNAs: MBI-36, MBII-48, MBII-52 and MBII-85, in mouse brain using in situ hybridization. All of these genes were expressed in the hippocampus and, except for MBII-85, their levels in ventral parts were higher than those in dorsal parts. Using quantitative real-time polymer chain reaction we determined hippocampal expression changes after contextual fear conditioning in mice. Ninety minutes, but not 25 h, after conditioning, we observed significant downregulation of MBII-48 and upregulation of MBII-52. Our finding that the expression of MBII-48 and MBII-52 is regulated during learning suggests that these snoRNAs have an important role in higher brain function.

Type: Article
Title: Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus
DOI: 10.1046/j.1460-9568.2003.03026.x
Keywords: 5-HT receptor, consolidation, gene expression, memory, snoRNA, RIBOSE METHYLATION, PRERIBOSOMAL RNA, MESSENGER-RNAS, LESIONS, RECEPTORS, DORSAL, MEMORY, IDENTIFICATION, INDUCTION, AMYGDALA
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: http://discovery.ucl.ac.uk/id/eprint/185755
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item