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Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis

Cau, E; Wilson, SW; (2003) Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis. DEVELOPMENT , 130 (11) 2455 - 2466. 10.1242/dev.00452.

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Abstract

The homeodomain transcription factor Floating head (FIh) is required for the generation of neurones in the zebrafish epiphysis. It regulates expression of two basic helix loop helix (bHLH) transcription factor encoding genes, ash1a (achaete/scute homologuela) and neurogenin1 (ngn1), in epiphysial neural progenitors. We show that ash1a and ngn1 function in parallel redundant pathways to regulate neurogenesis downstream of flh. Comparison of the epiphysial phenotypes of flh mutant and of ash1a/ngn1 double morphants reveals that reduced expression of ash1a and ngn1 can account for most of the neurogenesis defects 2455 in the flh-mutant epiphysis but also shows that Flh has additional activities. Furthermore, different cell populations show different requirements for ash1a and ngn1 within the epiphysis. These populations do not simply correspond to the two described epiphysial cell types: photoreceptors and projection neurones. These results suggest that the genetic pathways that involve ash1a and ngn1 are common to both neuronal types.

Type: Article
Title: Ash1a and Neurogenin1 function downstream of Floating head to regulate epiphysial neurogenesis
DOI: 10.1242/dev.00452
Keywords: neurogenesis, bHLH transcription factor, floating head, prepattern, epiphysis, zebrafish, CENTRAL-NERVOUS-SYSTEM, CRANIAL SENSORY GANGLIA, ACHAETE-SCUTE, BHLH GENES, DROSOPHILA-MELANOGASTER, NEURAL DIFFERENTIATION, CELL-DIFFERENTIATION, LATERAL INHIBITION, ORGAN PRECURSORS, ZEBRAFISH BRAIN
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: http://discovery.ucl.ac.uk/id/eprint/185747
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