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Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out

Simpson, RJ; Debnam, ES; Laftah, AH; Solanky, N; Beaumont, N; Bahram, S; Schumann, K; (2003) Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out. BLOOD , 101 (8) 3316 - 3318. 10.1182/blood-2002-10-3112.

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Abstract

Hereditary hemochromatosis is a common iron-loading disorder found in populations of European descent. It has been proposed that mutations causing loss of function of HFE gene result in reduced iron incorporation into immature duodenal crypt cells. These cells then overexpress genes for iron absorption, leading to inappropriate cellular iron balance, a persistent iron deficiency of the duodenal mucosa, and increased iron absorption. The objective was to measure duodenal iron content in We knock-out mice to test whether the mutation causes a persistent decrease in enterocyte iron concentration. In both normal and We knock-out mice, duodenal nonheme iron content was found to correlate with liver iron stores (P < .001, r = 0.643 and 0.551, respectively), and this effect did not depend on dietary iron levels. However, duodenal iron content was reduced in Hfe knockout mice for any given content of liver iron stores (P < .001). (C) 2003 by The American Society of Hematology.

Type: Article
Title: Duodenal nonheme iron content correlates with iron stores in mice, but the relationship is altered by Hfe gene knock-out
DOI: 10.1182/blood-2002-10-3112
Keywords: HEREDITARY HEMOCHROMATOSIS, ABSORPTION, PROTEIN, MECHANISMS, MOUSE, ACCUMULATION, ENTEROCYTES, TRANSFERRIN, DEFICIENCY, METABOLISM
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: http://discovery.ucl.ac.uk/id/eprint/185530
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