Yates, T; Hebden, JC; Gibson, A; Everdell, N; Arridge, SR; Douek, M; (2005) Optical tomography of the breast using a multi-channel time-resolved imager. PHYSICS IN MEDICINE AND BIOLOGY , 50 (11) 2503 - 2517. 10.1088/0031-9155/50/11/005.
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A time-resolved optical tomography system has been used to generate cross-sectional images of the human breast. Images are reconstructed using an iterative, nonlinear algorithm and measurements of mean photon flight time relative to those acquired on a homogeneous reference phantom. Thirty-eight studies have been performed on three healthy volunteers and 21 patients with a variety of breast lesions including cancer. We have successfully detected 17 out of 19 lesions, and shown that optical images of the healthy breast of the same volunteer display a heterogeneity which is repeatable over a period of months. However, results also indicate that the lack of accurate quantitation of optical parameters and limited morphological information limits the ability to characterize different types of lesions and distinguish benign from malignant tissues. Drawbacks of our current methodology and plans for overcoming them are discussed.
|Title:||Optical tomography of the breast using a multi-channel time-resolved imager|
|Keywords:||MAMMOGRAPHY, RECONSTRUCTION, SCATTERING, PHANTOM, TUMORS|
|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Surgery and Interventional Science (Division of) > Research Department of General Surgery|
UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering
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