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Intellectual performance after presymptomatic cranial radiotherapy for leukaemia: Effects of age and sex

Christie, D; Leiper, AD; Chessells, JM; Vargha-Khadem, F; (1995) Intellectual performance after presymptomatic cranial radiotherapy for leukaemia: Effects of age and sex. Archives of Disease in Childhood , 73 (2) pp. 136-140. 10.1136/adc.73.2.136.

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Abstract

Cognitive outcome, as measured by verbal and performance IQs, was compared in 35 girls and 47 boys who were in first remission for acute lymphoblastic leukaemia. All children had received presymptomatic cranial radiotherapy and intrathecal methotrexate. The mean age at diagnosis was 4·2 years and the mean elapsed time from initial diagnosis tointellectual assessment was 7·1 years. Results showed that children irradiated before the age of 4 years were impaired in certain aspects of non-verbal ability, as well as in measures of short term memory and attention, calculated by factor scores derived from selected subtests of the IQ test. Subtests requiring verbal and nonverbal reasoning showed the greatest impairment after early diagnosis and treatment. In addition girls were selectively impaired in verbal IQ and other aspects of verbal ability, with the degree of impairment exacerbated by early treatment. No relationship was found between degree of impairment and either time since treatment or number of methotrexate injections. It is concluded that early age at irradiation increases the risk of impaired intellectual outcome, particularly in girls.

Type: Article
Title: Intellectual performance after presymptomatic cranial radiotherapy for leukaemia: Effects of age and sex
DOI: 10.1136/adc.73.2.136
UCL classification: UCL > School of Life and Medical Sciences
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Child Health
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UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health Care
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URI: http://discovery.ucl.ac.uk/id/eprint/184203
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