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Individual differences in true and false memory retrieval are related to white matter brain microstructure.
Journal of Neuroscience
8698 - 8703.
We sometimes vividly remember things that did not happen, a phenomenon with general relevance not only in the court-room. It is unclear, to what extent individual differences in false memories are driven by anatomical differences in memory relevant brain regions. Here we show in humans that microstructural properties of different white matter tracts as quantified using Diffusion Tensor Imaging (DTI) are strongly correlated with true and false memory recollection. To investigate these hypotheses we tested a large group of participants in a version of the Deese-Roediger-McDermott (DRM) paradigm (recall and recognition) and subsequently obtained DTI images. A voxel-based whole-brain level linear regression analysis was performed to relate fractional anisotropy to indices of true and false memory recall and recognition. True memory was correlated to diffusion anisotropy in the inferior longitudinal fascicle, the major connective pathway of the medial temporal lobe, whereas a greater proneness to retrieve false items was related to the superior longitudinal fascicle connecting fronto-parietal structures. Our results show that individual differences in white-matter micro-structure underlie true and false memory performance.
|Title:||Individual differences in true and false memory retrieval are related to white matter brain microstructure|
|Open access status:||An open access version is available from UCL Discovery|
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|UCL classification:||UCL > School of Life and Medical Sciences > Faculty of Brain Sciences > Psychology and Language Sciences (Division of) > Institute of Cognitive Neuroscience
UCL > School of Life and Medical Sciences > Faculty of Life Sciences
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