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Allelic imbalance and biochemical outcome after radical prostatectomy

Bott, SRJ; Masters, JRW; Parkinson, MC; Kirby, RS; Feneley, M; Hooper, J; Williamson, M; (2006) Allelic imbalance and biochemical outcome after radical prostatectomy. PROSTATE CANCER P D , 9 (2) 160 - 168. 10.1038/sj.pcan.4500862.

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Abstract

Objective: To compare the incidence of allelic imbalance ( AI) in men with rapid disease progression with those who remained disease free after radical prostatectomy, with the aim of identifying genetic markers to predict prognosis and guide further treatment.Patients and methods: Tumour and normal DNA were extracted from two matched groups of 31 men with extracapsular node-negative (pT3N0) prostate cancer who had undergone radical prostatectomy. One group comprised men who developed biochemical recurrence within 2 years of surgery and one group were prostate-specific antigen (PSA) free for at least 3 years. Men were matched for Gleason grade, preoperative PSA and pathological stage. Analysis was performed by genotyping.Results: Allelic imbalance was analysed using 30 markers, and was seen in at least one marker in 57 (92%) of the cases. Deletion at marker D10S211 (10p12.1) was significantly more common in the relapse group than the non-relapse group ( 35 vs 5%, P = 0.03).Conclusions: This study demonstrates significant association between AI on chromosome 10 and biochemical progression after radical prostatectomy.

Type: Article
Title: Allelic imbalance and biochemical outcome after radical prostatectomy
DOI: 10.1038/sj.pcan.4500862
Keywords: radical prostatectomy, allelic imbalance, recurrence, prognosis, 10p12, TUMOR-SUPPRESSOR GENE, PROSTATIC INTRAEPITHELIAL NEOPLASIA, CHROMOSOME ARM 16Q, PROGNOSTIC-FACTORS, RETROPUBIC PROSTATECTOMY, DELETED REGIONS, CANCER CONTROL, HIGH-GRADE, HETEROZYGOSITY, LOCI
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: http://discovery.ucl.ac.uk/id/eprint/182557
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