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Neurotransmitter receptors in the life and death of oligodendrocytes

Karadottir, R; Attwell, D; (2007) Neurotransmitter receptors in the life and death of oligodendrocytes. NEUROSCIENCE , 145 (4) 1426 - 1438. 10.1016/j.neuroscience.2006.08.070. Gold open access

Abstract

Oligodendrocytes are crucial to the function of the mammalian brain: they increase the action potential conduction speed for a given axon diameter and thus facilitate the rapid flow of information between different brain areas. The proliferation and differentiation of developing oligodendrocytes, and their myelination of axons, are partly controlled by neurotransmitters. In addition, in models of conditions like stroke, periventricular leukomalacia leading to cerebral palsy, spinal cord injury and multiple sclerosis, oligodendrocytes are damaged by glutamate and, contrary to dogma, it has recently been discovered that this damage is mediated in part by N-methyl-D-aspartate receptors. Mutations in oligodendrocyte neurotransmitter receptors or their interacting proteins may cause defects in CNS function. Here we review the roles of neurotransmitter receptors in the normal function, and malfunction in pathological conditions, of oligodendrocytes. (C) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.

Type: Article
Title: Neurotransmitter receptors in the life and death of oligodendrocytes
Open access status: An open access publication
DOI: 10.1016/j.neuroscience.2006.08.070
Publisher version: http://ukpmc.ac.uk/abstract/MED/17049173
Keywords: glutamate, NMDA, development, ischemia, cerebral palsy, multiple sclerosis, RAT OPTIC-NERVE, CORPUS-CALLOSUM SLICE, GLIAL PROGENITOR CELLS, AMINO-ACID RECEPTORS, WHITE-MATTER DAMAGE, HUMAN GLIOMA-CELLS, SPINAL-CORD SLICE, GLUTAMATE-RECEPTOR, PRECURSOR CELLS, MEDIATED EXCITOTOXICITY
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology
URI: http://discovery.ucl.ac.uk/id/eprint/182505
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