UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

An appraisal of the histopathological assessment of liver fibrosis

Standish, RA; Cholongitas, E; Dhillon, A; Burroughs, AK; Dhillon, AP; (2006) An appraisal of the histopathological assessment of liver fibrosis. GUT , 55 (4) 569 - 578. 10.1136/gut.2005.084475.

Full text not available from this repository.

Abstract

One of the most important aspects of the histopathological assessment of liver biopsies in the setting of chronic liver disease is determination of the degree of fibrosis and architectural change. Most of the work in this regard has been concerned with chronic viral hepatitis. This article attempts to assess critically our current and historical biopsy practice, from subjective fibrosis scoring systems to biopsy sample size; and the appropriate use of the data that scoring systems generate in the research and clinical setting. An understanding of the limitations of each of the components of the fibrosis assessment process can help to devise appropriate protocols to ensure that the information obtained is optimised, and its degree of reliability appreciated. It is only from this starting point that recently promulgated antifibrotic medications and "non-invasive" liver fibrosis assessment techniques can be evaluated properly.

Type:Article
Title:An appraisal of the histopathological assessment of liver fibrosis
DOI:10.1136/gut.2005.084475
Keywords:CHRONIC HEPATITIS-C, CHRONIC VIRAL-HEPATITIS, TRUCUT-TYPE NEEDLE, VIRUS-INFECTION, SAMPLING VARIABILITY, IMAGE-ANALYSIS, SEMIQUANTITATIVE SCORES, HISTOLOGICAL-EVALUATION, QUANTITATIVE ASSESSMENT, TRANSIENT ELASTOGRAPHY
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Wolfson Institute and Cancer Institute Administration > Cancer Institute > Research Department of Pathology

Archive Staff Only: edit this record