UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Progress made towards the development of a CMV peptide vaccine

Paston, SJ; Dodi, IA; Madrigal, JA; (2004) Progress made towards the development of a CMV peptide vaccine. HUMAN IMMUNOLOGY , 65 (5) pp. 544-549.

Full text not available from this repository.

Abstract

Cytomegalovirus disease still remains a major cause of morbidity and mortality in hematopoietic stem cell transplantation recipients. The cell-mediated immune response is essential in the maintenance of latency and the resolution of primary infections. The identification of immunodominant cytomegalovirus antigens has enabled researchers to determine the best candidate antigens to be included in a cytomegalovirus vaccine. Such a vaccine would have to stimulate both a cell-mediated and humoral immune response. Recent advances have enabled the rapid identification of minimal cytotoxic epitopes required to trigger such responses. Epitope mapping to date has mainly focused on the pp65 antigen but other antigens such as IE1 are starting to be mapped. A human leukocyte antigen allele hierarchy is starting to emerge that is dependent on the alleles present in an individual; this is relevant when considering what peptides should be included in a vaccine. This review looks at the current methods available for epitope mapping and the progress that has been made to date

Type: Article
Title: Progress made towards the development of a CMV peptide vaccine
Additional information: Language: EnglishSubset: IMJournal code: 0008010936Document status: In-ProcessPublication model: PrintDataStar source field: Human immunology, {Hum-Immunol}, May 2004, vol. 65, no. 5, p. 544-9, 43 refs, ISSN: 0198-8859DataStar update date: 20041228
Keywords: allele, ALLELES, antigen, ANTIGENS, CELL, Cytomegalovirus, DISEASE, epitope, hematopoietic-stem-cell-transplantation, human, immune-response, infection, language, leukocyte antigen, LONDON, medical-school, model, morbidity, mortality, peptide, publication, recipient, RESPONSES, review, TRANSPLANTATION, United-Kingdom, university
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Haematology
URI: http://discovery.ucl.ac.uk/id/eprint/181946
Downloads since deposit
0Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item