UCL logo

UCL Discovery

UCL home » Library Services » Electronic resources » UCL Discovery

Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography

Hebden, JC; Gibson, A; Austin, T; Yusof, RM; Everdell, N; Delpy, DT; ... Wyatt, JS; + view all (2004) Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography. PHYS MED BIOL , 49 (7) 1117 - 1130. 10.1088/0031-9155/49/7/003.

Full text not available from this repository.

Abstract

Induced haemodynamic and blood oxygenation changes occurring within the brain of a ventilated newborn infant have been imaged in three dimensions using optical tomography. Noninvasive measurements of the flight times of transmitted light were acquired during illumination of the brain by laser pulses at wavelengths of 780 nm and 815 nm. The oxygen and carbon dioxide partial pressures were adjusted through alterations to the ventilator settings, resulting in changes to the cerebral blood volume and oxygenation. Three-dimensional images were generated using the physiologically associated differences in the measured data, obviating the need for data calibration using a separate reference measurement. The results exhibit large changes in absorption coefficient at both wavelengths. Images corresponding to differences in concentrations of oxyand deoxyhaemoglobin are in qualitative agreement with known physiological data.

Type:Article
Title:Imaging changes in blood volume and oxygenation in the newborn infant brain using three-dimensional optical tomography
DOI:10.1088/0031-9155/49/7/003
Keywords:NEAR-INFRARED SPECTROSCOPY, HEMODYNAMICS, BEDSIDE, LIGHT, FLOW
UCL classification:UCL > School of BEAMS > Faculty of Engineering Science > Computer Science
UCL > School of BEAMS > Faculty of Engineering Science > Medical Physics and Bioengineering

Archive Staff Only: edit this record