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Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.

Hernandez, D; Janmohamed, A; Chandan, P; Phillips, IR; Shephard, EA; (2004) Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters. Pharmacogenetics , 14 (2) 117 - 130.

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Abstract

To date, six flavin-containing monooxygenase (FMO) genes have been identified in humans, FMOs 1, 2, 3, 4 and 6, which are located within a cluster on chromosome 1, and FMO5, which is located outside the cluster. The objectives were to review and update current knowledge of the structure and expression profiles of these genes and of their mouse counterparts and to determine, via a bioinformatics approach, whether other FMO genes are present in the human and mouse genomes.

Type:Article
Title:Organization and evolution of the flavin-containing monooxygenase genes of human and mouse: identification of novel gene and pseudogene clusters.
Location:England
Language:English
Keywords:Amino Acid Sequence, Animals, Base Sequence, Chromosomes, Artificial, Bacterial, Chromosomes, Human, Pair 1, Cloning, Molecular, DNA, Evolution, Molecular, Female, Gene Library, Humans, Male, Mice, Mice, Inbred C57BL, Molecular Sequence Data, Multigene Family, Open Reading Frames, Oxygenases, Phylogeny, Pseudogenes, Rats, Sequence Homology, Amino Acid, Sequence Homology, Nucleic Acid, Tissue Distribution
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Life Sciences > Biosciences (Division of)
UCL > School of BEAMS > Faculty of Engineering Science > Biochemical Engineering

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