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The interleukin-6 gene-174G > C and-572G > C promoter polymorphisms are related to cerebral aneurysms

Morgan, L; Cooper, J; Montgomery, H; Kitchen, N; Humphries, SE; (2006) The interleukin-6 gene-174G > C and-572G > C promoter polymorphisms are related to cerebral aneurysms. J NEUROL NEUROSUR PS , 77 (8) 915 - 917. 10.1136/jnnp.2005.081976. Gold open access

Abstract

Background and aims: An important part is played by inflammation in intracranial aneurysm formation. The hypothesis that there is an association of the proinflammatory cytokine interleukin-6 (IL-6) genotypes (-572G > C and -174G > C) with intracranial aneurysms was tested.Methods: IL-6 genotypes were determined in 91 Caucasian patients with aneurysms and compared with 2720 healthy UK controls.Results: For both polymorphisms, the distribution of the genotypes and estimated allele frequency were different between the control group and the aneurysm group. For -572G > C, a higher frequency of the C allele (p = 0.001) and more people homozygous for the C allele were found among those with aneurysms than among the controls (4.4% v 0.3%, p = 0.001). For -174G > C, more people homozygous for the C allele were found among the controls than among those with aneurysm (18% v 7%, p = 0.007). The 572C/174G haplotype was associated with an increased risk of aneurysms, with the relative risk compared with the common haplotype being 1.89 and that for the -572G/174C haplotype being 0.58 (p < 0.0005).Conclusion: This is the first study to show that IL-6 promoter polymorphisms are associated with intracranial aneurysmal disease. Whether this association is with the development, progression or rupture of such aneurysms, or represents survivor bias, is unclear.

Type:Article
Title:The interleukin-6 gene-174G > C and-572G > C promoter polymorphisms are related to cerebral aneurysms
Open access status:An open access publication
DOI:10.1136/jnnp.2005.081976
Publisher version:http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC2077617/?tool=pubmed
Keywords:CORONARY-HEART-DISEASE, SUBARACHNOID HEMORRHAGE, INFLAMMATORY CYTOKINES, G/C POLYMORPHISM, GENE PROMOTER, ASSOCIATION, PLASMA, RISK, EXPRESSION, INFARCTION
UCL classification:UCL > School of Life and Medical Sciences > Faculty of Medical Sciences > Medicine (Division of) > Clinical Physiology
UCL > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science

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