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The SAAPdb Web Resource: A Large-Scale Structural Analysis of Mutant Proteins

Hurst, JM; McMillan, LEM; Porter, CT; Allen, J; Fakorede, A; Martin, ACR; (2009) The SAAPdb Web Resource: A Large-Scale Structural Analysis of Mutant Proteins. HUM MUTAT , 30 (4) 616 - 624. 10.1002/humu.20898.

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Abstract

The Single Amino Acid Polymorphism database (SAAPdb) is it new resource for the analysis and visualization of the structural effects of mutations. Our analytical approach is to map single nucleotide polymorphisms (SNPs) and pathogenic deviations (PDs) to protein structural data held within the Protein Data Bank. By mapping mutations onto protein structures, we can hypothesize whether the mutant residues will have any local structural effect that may "explain" a deleterious phenotype. Our prior work used a similar approach to analyze mutations within a single protein. An analysis of the contents of SAAPdb indicates that there are clear differences in the sequence and structural characteristics of SNPs and PDs, and that PDs are more often explained by Our structural analysis. This mapping and analysis is a useful resource for the Mutation community and is publicly available at http://www.bioinf.org.uk/saap/db/. Hum Mutat 30, 616-624, 2009. (C) 2009 Wiley,Liss, Inc.

Type: Article
Title: The SAAPdb Web Resource: A Large-Scale Structural Analysis of Mutant Proteins
DOI: 10.1002/humu.20898
Keywords: SAAPdb, SNP, pathogenic deviations, disease, database, structural bioinformatics, SINGLE NUCLEOTIDE POLYMORPHISMS, NON-SYNONYMOUS SNPS, SUPPRESSOR PROTEIN, CIS-PROLINE, DISEASE, MUTATIONS, SEQUENCE, DATABASE, GLUCOSE-6-PHOSPHATE-DEHYDROGENASE, SUBSTITUTION
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology
URI: http://discovery.ucl.ac.uk/id/eprint/179713
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